Endocrine Abstracts

Introduction: Significant hypoglycaemia is a rare but well recognised presenting feature of secondary adrenal insufficiency. Such hypoadrenalism may be caused by intrinsic hypothalamo-pituitary disease (pituitary adenoma), exogenous steroid therapy, and uncommonly by hypophysitis and pituitary secondaries from malignant disease.Case presentation: A 73-year-old woman presented acutely with confusion, agitation, and a...

Introduction: Significant hypoglycaemia is a rare but well recognised presenting feature of secondary adrenal insufficiency. Such hypoadrenalism may be caused by intrinsic hypothalamo-pituitary disease (pituitary adenoma), exogenous steroid therapy, and uncommonly by hypophysitis and pituitary secondaries from malignant disease.Case presentation: A 73-year-old woman presented acutely with confusion, agitation, and a...

Introduction: The polycystic ovary syndrome is the commonest cause for hyperandrogenism in young women. However, in older women, adrenal and ovarian tumours are more common, particularly if (a) hyperandrogenism is of short duration, (b) causes significant clinical androgenisation, and (c) is biochemically severe. We present an elderly woman who presented diagnostic and therapeutic challenges on account of her comorbidities.Case Present...

Introduction: There is no consensus about the management of thymic enlargement in Graves’ disease (GD). If imaging indicates ‘benign’ thymic appearances, and interval scans are stable, most authorities advocate no intervention until thyrotoxicosis is controlled. We present 3 patients with GD and incidentally found thymic enlargement.Case presentations: a. A 37-year-old female presented acutely with osmotic symptoms, a weight ...

Introduction: The polycystic ovary syndrome is the commonest cause for hyperandrogenism in young women. However, in older women, adrenal and ovarian tumours are more common, particularly if (a) hyperandrogenism is of short duration, (b) causes significant clinical androgenisation, and (c) is biochemically severe. We present an elderly woman who presented diagnostic and therapeutic challenges on account of her comorbidities.Case Present...

Introduction: There is no consensus about the management of thymic enlargement in Graves’ disease (GD). If imaging indicates ‘benign’ thymic appearances, and interval scans are stable, most authorities advocate no intervention until thyrotoxicosis is controlled. We present 3 patients with GD and incidentally found thymic enlargement.Case presentations: a. A 37-year-old female presented acutely with osmotic symptoms, a weight ...

Introduction Lithium (Li) is an effective treatment for bipolar and schizo-affective disorders. It has a narrow therapeutic index, and produces common side effects when this is exceeded. Li causes endocrine disruption by predictable and some hitherto unclear mechanisms. We present a subject who developed multiple Li induced endocrinopathies concurrently, and was a therapeutic challenge. Case presentation and investigations Mr. DM had been on Li for 10 years and developed polyu...